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The following CVOTs, relative to DPP-4i and GLP-1RAs, have been identified and included in this review: EXAMINE, SAVOR-TIMI53, TECOS, CARMELINA, CAROLINA, ELIXA, SUSTAIN 6, EXSCEL, HARMONY, LEADER, PIONEER 6, REWIND, and AMPLITUDE-O [47,48,49, 53, 54, 56,57,58,59,60,61,62,63]
This connection was demonstrated in rat studies
Beyond the numbers, the best candidates are those committed to making lifestyle modifications, including nutritional improvements and increased physical activity, as the medication is most effective when used as part of a holistic health plan
Weir GC, Bonner-Weir S
Preclinical studies in rodent models have examined its interactions with nitric oxide signaling, angiogenic factors including VEGF, fibroblast migration, and collagen synthesis in various tissue types
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