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Some people who begin using semaglutide injections report headaches, but interestingly, one trial reported headaches in 14% of the semaglutide users and 10% in the group using the placebo, and another large clinical trial showed that the rate of individuals who reported headaches was also very close to those reported by the placebo group, so it is hard to know if the semaglutide is directly related to the headaches

Gupta, M

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In fact, Bliddal et al explicitly say that mechanistic conclusions cannot be drawn. But they do cite preclinical data suggesting possible anti-inflammatory and anti-degradative effects of this class of drugs

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