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They can evaluate potential contributing factors, including: Review of all current medications for weight-affecting drugs Assessment for underlying medical conditions (thyroid dysfunction, Cushing's syndrome, polycystic ovary syndrome) Consideration of dose adjustment if you are not yet on an optimal maintenance dose Evaluation for fluid retention or other medical causes Pregnancy testing if appropriate Seek urgent medical attention if you experience severe, persistent abdominal pain (which could indicate pancreatitis or gallbladder disease), persistent vomiting, yellowing of the skin or eyes, or sudden breathlessness with leg swelling

When injected, they keep a person feeling full for days instead of minutes, leading to rapid weight loss of about 15 per cent of body weight within a year

Bram Brouwers, Ph.D., and Meri Kay Scott, Ph.D., for trial design advice