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Important early changes occur before severe cell damage take place but no universal markers have yet been identified 21
Dosing is discussed at all because cagrilintide produced clinically meaningful weight reduction as a standalone agent in a phase 2 dose-finding trial, and because it is the amylin half of CagriSema the fixed-dose cagrilintide/semaglutide combination that Novo Nordisk filed with the FDA in December 2025
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