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The Phase 2 clinical trial showed roughly 2-3 kg more fat loss than placebo over 12 weeks, with no impact on blood sugar, insulin, IGF-1, or any hormonal marker

The FDA's evaluation of weight loss injections has included extensive kidney safety monitoring through clinical trials and post-marketing surveillance

For example, Novo Nordisk's oral formulation of semaglutide for diabetes Rybelsus needs to be dosed in the fasting state, with patients not eating or drinking for at least 30 minutes afterwards

Usually that means carbs

As with all subcutaneous injectable medications, retatrutide may cause localised reactions at the injection site