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Ichthyosis is usually caused by genetic mutations that affect various cellular functions, including DNA repair, lipid synthesis, and adhesions, resulting in skin barrier dysfunction (Limmer et al., 2020)

Comprehensive plasma metabolomics studies of ME/CFS patients have identified significant dysregulation in lipid and energy metabolism, notably revealing decreased levels of circulating carnitine and choline

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Data availability The data presented in this study are available on request from corresponding author

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