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Derived from epoxomicin, the , -epoxyketone moiety of carfilzomib binds to both the hydroxyl group and the free -amino group of Thr 1 in the catalytic 5 subunits, forming a morpholino adduct and blocking access of substrate proteins to the catalytic residues 77,78,79
Hornix BE, Havekes R, Kas MJH
Frecuencia: 1 vez/semana 812 semanas
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