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Its active site contains a cobalt ion with a + 3 charge at the center

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Activation of Thiamine Thiamine is rapidly converted to its active form, thiamine pyrophosphate, TPP, by the enzyme thiamine pyrophosphokinase 1, TPK1

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We then compared the renal efficiency of carnitine and TMAO excretion by using fractional excretion of carnitine (FeCarnitine) and fractional excretion of TMAO (FeTMAO) referenced with a clinical formula, FeNa [22]

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