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March 18, 2021

2 While all forms of B12 are well-tolerated by many, methylcobalamin is the form of B12 that is most known for causing some mild side effects related to methylation

demonstrated similar effects that were not suppressed by reserpine, propranolol, or phentolamine, thereby suggesting a direct mode of action [3234]

Collectively, these findings highlight USP8 as a key mediator of targeted therapy resistance across multiple cancers and agents

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