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Moreover, this study also found that short-term antibiotic intervention could increase the frequency of Tregs in the intestinal lamina propria at one week post-immunization and increase Tregs in the extra-intestine lymphoid tissue at 3 or 4 weeks post-immunization, while Teff cells were reduced in the extra-intestine lymphoid tissue at the early stage of disease (14)

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Group 5 received local MSC and G-CSF via Hydrogel and an intravenous injection of MSC

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