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Studies in obese mice reported changes in fat mass and metabolic markers after NNMT inhibition

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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This preserves nicotinamide for NAD production, improving energy and fat-burning efficiency

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