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For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%)

Having a plan in place When you know youre going to stop semaglutide, creating a plan with your doctor to compensate for possible rebound effects can help

Polymorphisms of glutathione S-transferase in skin cancers in a Japanese population [PMID: 22169897] Laboratory literature summary: Polymorphisms of glutathione S-transferase in skin cancers in a Japanese population

In that population, it was not uncommon for people to inadvertently get pregnant because they had lost such a significant amount of weight that their ovulation kind of recalibrated. If people experienced similar rapid weight loss due to GLP-1s, she says, There is potential for them to start to re-ovulate. Yet results across weight-loss studies are inconsistent

Planning pregnancy while managing weight and metabolic health isnt the easiest path, but with good information, good medical support, and strategic planning, you can absolutely navigate this successfully