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The MLF-treated mice had notably less weight loss than the DSS group, and the effect of 0.2 g/kg dose and 0.4 g/kg dose MLF was more significant (Figure 5A)
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Future frameworks will likely need to incorporate guidance for engineered strains, synbiotics, microbial consortia, and microbiome-based therapeutics, extending the FAO/WHO principles to more complex products while maintaining their core focus on strain specificity, safety, and evidence-based health benefits (531)
