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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

Three-dimensional variability of HSV-2 gB in prefusion conformation was resolved using three orthogonal principle modes and a filter resolution of 7 with 281,789 particles from non-uniform refinement