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Enzymatic conjugation of chlorambucil with glutathione by research subjects [PMID: 1930278] Laboratory literature summary: Enzymatic conjugation of chlorambucil with glutathione by research subjects glutathione S-transferases and inhibition by ethacrynic acid

This result suggested they might be recognizing nontarget features, such as the GGS linker between lysozyme and RNAP, rather than authentic substrate residues

S., Kita, K., Ochi, T., Zeller, K

A typical strategy is a short trial, evaluate response, then repeat cycles as clinically indicated while addressing lifestyle and underlying drivers

If no adverse effects occur, increase to 300-500mcg for the remainder of the cycle