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Consequently, LX1031, an oral inhibitor of tryptophan hydroxylase, the key enzyme for mucosal serotonin synthesis has been successful for treatment of patients with non-constipating IBS [202]

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CagriSema cagrilintide 2.4 mg plus semaglutide 2.4 mg was submitted to the FDA on 18 December 2025 for chronic weight management, with the agency expected to review it during 2026