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Variants in selenoprotein P may similarly alter selenium utilization, while polymorphisms in catechol-O-methyltransferase (COMT) and other metabolic enzymes could influence responsiveness to polyphenols (271273)
23. Zecha, J., Meng, C., Zolg, D.P., Samaras, P., Wilhelm, M., and Kuster, B
moderate renal impairment (eGFR 30-45 ml/min) has been observed to increase plasma levels of sitagliptin 2-fold, and severe renal impairment can increase plasma levels 4-fold
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In OC development, the involvement of -catenin in the Wnt/-catenin signaling pathway has been observed in stem cell proliferation and differentiation, as well as in drug resistance in OCSCs
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